Differential Expression of the Middle East Respiratory Syndrome Coronavirus Receptor in the Upper Respiratory Tracts of Humans and Dromedary Camels.
Identifieur interne : 001300 ( Main/Exploration ); précédent : 001299; suivant : 001301Differential Expression of the Middle East Respiratory Syndrome Coronavirus Receptor in the Upper Respiratory Tracts of Humans and Dromedary Camels.
Auteurs : W. Widagdo [Pays-Bas] ; V Stalin Raj [Pays-Bas] ; Debby Schipper [Pays-Bas] ; Kimberley Kolijn [Pays-Bas] ; Geert J L H. Van Leenders [Pays-Bas] ; Berend J. Bosch [Pays-Bas] ; Albert Bensaid [Espagne] ; Joaquim Segalés [Espagne] ; Wolfgang Baumg Rtner [Allemagne] ; Albert D M E. Osterhaus [Pays-Bas] ; Marion P. Koopmans [Pays-Bas] ; Judith M A. Van Den Brand [Pays-Bas] ; Bart L. Haagmans [Pays-Bas]Source :
- Journal of virology [ 1098-5514 ] ; 2016.
Descripteurs français
- KwdFr :
- ARN messager (génétique), ARN messager (métabolisme), Animaux, Chameaux, Coronavirus du syndrome respiratoire du Moyen-Orient (physiologie), Dipeptidyl peptidase 4 (génétique), Dipeptidyl peptidase 4 (métabolisme), Humains, Immunohistochimie, Infections à coronavirus (transmission), Infections à coronavirus (virologie), Muqueuse respiratoire (métabolisme), Muqueuse respiratoire (virologie), Récepteurs viraux (génétique), Récepteurs viraux (métabolisme), Régulation de l'expression des gènes, Réplication virale.
- MESH :
- génétique : ARN messager, Dipeptidyl peptidase 4, Récepteurs viraux.
- métabolisme : ARN messager, Dipeptidyl peptidase 4, Muqueuse respiratoire, Récepteurs viraux.
- physiologie : Coronavirus du syndrome respiratoire du Moyen-Orient.
- virologie : Infections à coronavirus, Muqueuse respiratoire.
- transmission : Animaux, Chameaux, Humains, Immunohistochimie, Infections à coronavirus, Régulation de l'expression des gènes, Réplication virale.
English descriptors
- KwdEn :
- Animals, Camelus, Coronavirus Infections (transmission), Coronavirus Infections (virology), Dipeptidyl Peptidase 4 (genetics), Dipeptidyl Peptidase 4 (metabolism), Gene Expression Regulation, Humans, Immunohistochemistry, Middle East Respiratory Syndrome Coronavirus (physiology), RNA, Messenger (genetics), RNA, Messenger (metabolism), Receptors, Virus (genetics), Receptors, Virus (metabolism), Respiratory Mucosa (metabolism), Respiratory Mucosa (virology), Virus Replication.
- MESH :
- chemical , genetics : Dipeptidyl Peptidase 4, RNA, Messenger, Receptors, Virus.
- chemical , metabolism : Dipeptidyl Peptidase 4, RNA, Messenger, Receptors, Virus.
- metabolism : Respiratory Mucosa.
- physiology : Middle East Respiratory Syndrome Coronavirus.
- transmission : Coronavirus Infections.
- virology : Coronavirus Infections, Respiratory Mucosa.
- Animals, Camelus, Gene Expression Regulation, Humans, Immunohistochemistry, Virus Replication.
Abstract
Middle East respiratory syndrome coronavirus (MERS-CoV) is not efficiently transmitted between humans, but it is highly prevalent in dromedary camels. Here we report that the MERS-CoV receptor--dipeptidyl peptidase 4 (DPP4)--is expressed in the upper respiratory tract epithelium of camels but not in that of humans. Lack of DPP4 expression may be the primary cause of limited MERS-CoV replication in the human upper respiratory tract and hence restrict transmission.
DOI: 10.1128/JVI.02994-15
PubMed: 26889022
Affiliations:
- Allemagne, Espagne, Pays-Bas
- Basse-Saxe, Catalogne, Hollande-Méridionale, Utrecht (province)
- Barcelone, Hanovre, Rotterdam, Utrecht
- Université autonome de Barcelone, Université d'Utrecht
Links toward previous steps (curation, corpus...)
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Le document en format XML
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Bosch</name><affiliation wicri:level="4"><nlm:affiliation>Virology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Virology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName><orgName type="university">Université d'Utrecht</orgName></affiliation></author><author><name sortKey="Bensaid, Albert" sort="Bensaid, Albert" uniqKey="Bensaid A" first="Albert" last="Bensaid">Albert Bensaid</name><affiliation wicri:level="4"><nlm:affiliation>IRTA, Centre de Recerca en Sanitat Animal (CReSA), Campus de la Universitat Autònoma de Barcelona, Bellaterra (Cerdanyola del Vallès), Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>IRTA, Centre de Recerca en Sanitat Animal (CReSA), Campus de la Universitat Autònoma de Barcelona, Bellaterra (Cerdanyola del Vallès)</wicri:regionArea><orgName type="university">Université autonome de Barcelone</orgName><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Segales, Joaquim" sort="Segales, Joaquim" uniqKey="Segales J" first="Joaquim" last="Segalés">Joaquim Segalés</name><affiliation wicri:level="4"><nlm:affiliation>UAB, Centre de Recerca en Sanitat Animal (CReSA), Unitat Mixta IRTA-UAB, Campus de la Universitat Autònoma de Barcelona, Bellaterra (Cerdanyola del Vallès), Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>UAB, Centre de Recerca en Sanitat Animal (CReSA), Unitat Mixta IRTA-UAB, Campus de la Universitat Autònoma de Barcelona, Bellaterra (Cerdanyola del Vallès)</wicri:regionArea><orgName type="university">Université autonome de Barcelone</orgName><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Baumg Rtner, Wolfgang" sort="Baumg Rtner, Wolfgang" uniqKey="Baumg Rtner W" first="Wolfgang" last="Baumg Rtner">Wolfgang Baumg Rtner</name><affiliation wicri:level="3"><nlm:affiliation>Department of Pathology, University of Veterinary Medicine, Hannover, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Pathology, University of Veterinary Medicine, Hannover</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Hanovre</settlement></placeName></affiliation></author><author><name sortKey="Osterhaus, Albert D M E" sort="Osterhaus, Albert D M E" uniqKey="Osterhaus A" first="Albert D M E" last="Osterhaus">Albert D M E. Osterhaus</name><affiliation wicri:level="3"><nlm:affiliation>Department of Viroscience, Erasmus MC, Rotterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Viroscience, Erasmus MC, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Koopmans, Marion P" sort="Koopmans, Marion P" uniqKey="Koopmans M" first="Marion P" last="Koopmans">Marion P. Koopmans</name><affiliation wicri:level="3"><nlm:affiliation>Department of Viroscience, Erasmus MC, Rotterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Viroscience, Erasmus MC, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Van Den Brand, Judith M A" sort="Van Den Brand, Judith M A" uniqKey="Van Den Brand J" first="Judith M A" last="Van Den Brand">Judith M A. Van Den Brand</name><affiliation wicri:level="3"><nlm:affiliation>Department of Viroscience, Erasmus MC, Rotterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Viroscience, Erasmus MC, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Haagmans, Bart L" sort="Haagmans, Bart L" uniqKey="Haagmans B" first="Bart L" last="Haagmans">Bart L. Haagmans</name><affiliation wicri:level="3"><nlm:affiliation>Department of Viroscience, Erasmus MC, Rotterdam, The Netherlands b.haagmans@erasmusmc.nl.</nlm:affiliation><country wicri:rule="url">Pays-Bas</country><wicri:regionArea>Department of Viroscience, Erasmus MC, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author></analytic><series><title level="j">Journal of virology</title><idno type="eISSN">1098-5514</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Camelus</term><term>Coronavirus Infections (transmission)</term><term>Coronavirus Infections (virology)</term><term>Dipeptidyl Peptidase 4 (genetics)</term><term>Dipeptidyl Peptidase 4 (metabolism)</term><term>Gene Expression Regulation</term><term>Humans</term><term>Immunohistochemistry</term><term>Middle East Respiratory Syndrome Coronavirus (physiology)</term><term>RNA, Messenger (genetics)</term><term>RNA, Messenger (metabolism)</term><term>Receptors, Virus (genetics)</term><term>Receptors, Virus (metabolism)</term><term>Respiratory Mucosa (metabolism)</term><term>Respiratory Mucosa (virology)</term><term>Virus Replication</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>ARN messager (génétique)</term><term>ARN messager (métabolisme)</term><term>Animaux</term><term>Chameaux</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient (physiologie)</term><term>Dipeptidyl peptidase 4 (génétique)</term><term>Dipeptidyl peptidase 4 (métabolisme)</term><term>Humains</term><term>Immunohistochimie</term><term>Infections à coronavirus (transmission)</term><term>Infections à coronavirus (virologie)</term><term>Muqueuse respiratoire (métabolisme)</term><term>Muqueuse respiratoire (virologie)</term><term>Récepteurs viraux (génétique)</term><term>Récepteurs viraux (métabolisme)</term><term>Régulation de l'expression des gènes</term><term>Réplication virale</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Dipeptidyl Peptidase 4</term><term>RNA, Messenger</term><term>Receptors, Virus</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Dipeptidyl Peptidase 4</term><term>RNA, Messenger</term><term>Receptors, Virus</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>ARN messager</term><term>Dipeptidyl peptidase 4</term><term>Récepteurs viraux</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Respiratory Mucosa</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>ARN messager</term><term>Dipeptidyl peptidase 4</term><term>Muqueuse respiratoire</term><term>Récepteurs viraux</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term></keywords><keywords scheme="MESH" qualifier="transmission" xml:lang="en"><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Infections à coronavirus</term><term>Muqueuse respiratoire</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Coronavirus Infections</term><term>Respiratory Mucosa</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Camelus</term><term>Gene Expression Regulation</term><term>Humans</term><term>Immunohistochemistry</term><term>Virus Replication</term></keywords><keywords scheme="MESH" qualifier="transmission" xml:lang="fr"><term>Animaux</term><term>Chameaux</term><term>Humains</term><term>Immunohistochimie</term><term>Infections à coronavirus</term><term>Régulation de l'expression des gènes</term><term>Réplication virale</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Middle East respiratory syndrome coronavirus (MERS-CoV) is not efficiently transmitted between humans, but it is highly prevalent in dromedary camels. Here we report that the MERS-CoV receptor--dipeptidyl peptidase 4 (DPP4)--is expressed in the upper respiratory tract epithelium of camels but not in that of humans. Lack of DPP4 expression may be the primary cause of limited MERS-CoV replication in the human upper respiratory tract and hence restrict transmission.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Espagne</li><li>Pays-Bas</li></country><region><li>Basse-Saxe</li><li>Catalogne</li><li>Hollande-Méridionale</li><li>Utrecht (province)</li></region><settlement><li>Barcelone</li><li>Hanovre</li><li>Rotterdam</li><li>Utrecht</li></settlement><orgName><li>Université autonome de Barcelone</li><li>Université d'Utrecht</li></orgName></list><tree><country name="Pays-Bas"><region name="Hollande-Méridionale"><name sortKey="Widagdo, W" sort="Widagdo, W" uniqKey="Widagdo W" first="W" last="Widagdo">W. Widagdo</name></region><name sortKey="Bosch, Berend J" sort="Bosch, Berend J" uniqKey="Bosch B" first="Berend J" last="Bosch">Berend J. Bosch</name><name sortKey="Haagmans, Bart L" sort="Haagmans, Bart L" uniqKey="Haagmans B" first="Bart L" last="Haagmans">Bart L. Haagmans</name><name sortKey="Kolijn, Kimberley" sort="Kolijn, Kimberley" uniqKey="Kolijn K" first="Kimberley" last="Kolijn">Kimberley Kolijn</name><name sortKey="Koopmans, Marion P" sort="Koopmans, Marion P" uniqKey="Koopmans M" first="Marion P" last="Koopmans">Marion P. Koopmans</name><name sortKey="Osterhaus, Albert D M E" sort="Osterhaus, Albert D M E" uniqKey="Osterhaus A" first="Albert D M E" last="Osterhaus">Albert D M E. Osterhaus</name><name sortKey="Raj, V Stalin" sort="Raj, V Stalin" uniqKey="Raj V" first="V Stalin" last="Raj">V Stalin Raj</name><name sortKey="Schipper, Debby" sort="Schipper, Debby" uniqKey="Schipper D" first="Debby" last="Schipper">Debby Schipper</name><name sortKey="Van Den Brand, Judith M A" sort="Van Den Brand, Judith M A" uniqKey="Van Den Brand J" first="Judith M A" last="Van Den Brand">Judith M A. Van Den Brand</name><name sortKey="Van Leenders, Geert J L H" sort="Van Leenders, Geert J L H" uniqKey="Van Leenders G" first="Geert J L H" last="Van Leenders">Geert J L H. Van Leenders</name></country><country name="Espagne"><region name="Catalogne"><name sortKey="Bensaid, Albert" sort="Bensaid, Albert" uniqKey="Bensaid A" first="Albert" last="Bensaid">Albert Bensaid</name></region><name sortKey="Segales, Joaquim" sort="Segales, Joaquim" uniqKey="Segales J" first="Joaquim" last="Segalés">Joaquim Segalés</name></country><country name="Allemagne"><region name="Basse-Saxe"><name sortKey="Baumg Rtner, Wolfgang" sort="Baumg Rtner, Wolfgang" uniqKey="Baumg Rtner W" first="Wolfgang" last="Baumg Rtner">Wolfgang Baumg Rtner</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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